The BBSRC and NC3Rs are collaborating on a joint funding highlight notice to encourage the development of new and innovative models and approaches for ageing research, which reduce the current reliance on mammalian models, as well as address the gaps in terms of scientific utility and relevance to human ageing.
Applications should focus on the biology of ageing and the development of new models and approaches which could minimise the use of mammalian models, as well as providing new insights into the molecular, cellular and physiological events of ageing (and their association with disease).
Areas in scope include, but are not limited to, the fundamental biological mechanisms of the ageing process across the lifecourse, for example improving understanding of how ageing impacts on homeostasis/physiological function in the musculoskeletal, gastrointestinal, immune, cognitive, circadian and sensory systems.
The types of models and approaches the funders envisage will be supported include, but are not limited to:
- Cellular and tissue engineered systems (e.g. using stem cell technologies, human tissue)
- Systems biology approaches
- Mathematical and computational models
- Clinical and population data
- Non-mammalian organisms (e.g. Drosophila)1.
Proposals can be submitted to either the BBSRC or NC3Rs depending on the focus:
- For the BBSRC: Models relevant to healthy ageing.
- For the NC3Rs: Models of the ageing process with relevance to human disease and/or the development of co-morbidity.
A workshop will be held on 1 September 2017 in central London to bring together experts in ageing and age-related diseases, researchers using animal and non-animal approaches, and other stakeholders. The aims of the workshop are to discuss the advantages and limitations of existing model systems and the specifications and requirements for effective models of ageing, and to provide networking opportunities for developing collaborative, interdisciplinary research proposals.
Register for the event HERE
Please can you contact your Research Development Manager if you are interested in this funding opportunity.